PEAKS Studio--兼容DDA和DIA的蛋白质组学完整解决方案
PEAKS Studio是一个软件平台，为发现蛋白质组学提供完整的解决方案，包括蛋白质鉴定和定量、翻译后修饰（PTM）和序列变异（突变）的分析，以及肽/蛋白质从头测序
PEAKS Studio 13 提供完整的自下而上的蛋白质组学解决方案，具有更高的准确性、灵敏度和速度。PEAKS为各种应用更新了工作流程，例如深入的经典和非经典肽和蛋白质鉴定，使PEAKS成为独特的解决方案。从 DDA 到 DIA 数据支持，PEAKS Studio 13 提供了一个全面的解决方案，将您的研究提升到新的高度！
PEAKS Studio 13 引入了重新设计的 DDA 和 DIA 工作流程，通过增强的算法提供简化和用户友好的体验。PEAKS DIA 提供极具竞争力的处理时间和更高的性能，通过新型肽段和序列变体获得深入的数据洞察。现在，DIA 还可以通过新的“特征”选项卡获得完整的结果透明度。请检查下面的所有新功能！
PEAKS 和 DeepSuite 的新功能
高灵敏度 DIA：简化、准确、快速
糖蛋白质组学和糖组学：使用GlycanFinder进行高级结构鉴定
Proteoform Characterization：统一的自上而下和自下而上的工作流程
新抗原发现：组学驱动的免疫治疗见解
DeepSuite Lab 服务：AI 驱动的专家分析，用于肽段鉴定、从头测序等
PEAKS Studio 13 引入了重新设计的 DDA 和 DIA 工作流程，通过增强的算法提供简化和用户友好的体验。PEAKS DIA 提供极具竞争力的处理时间和更高的性能，通过新型肽段和序列变体获得深入的数据洞察。现在，DIA 还可以通过新的“特征”选项卡获得完整的结果透明度。请检查下面的所有新功能！
无与伦比的 DIA 性能
我们增强的 DIA 解决方案将加速您的发现，确保准确和全面的结果，从而提供复杂的生物学见解！
完整的结果透明度
的 New Feature 选项卡概述了与每个 DIA 识别步骤的所有特征关联，并允许用户调查、验证和确认结果。
使用序列变体和新型肽解锁暗蛋白质组
在人类和小鼠数据库中搜索人类胰蛋白酶消化物，在数据库搜索中鉴定出人类肽段，而使用新的 DIA SPIDER 作为突变物鉴定小鼠肽段：
其他新功能
PEAKS DIA Proteome
PEAKS DIA Peptidome
PEAKS DDA
Transition List Generator Tool
PRM Quantification
PEAKS: Advanced Proteomics SolutionPEAKS is a specialised tool that offers unrivalled peptide identification rates driven by deep learning technology integrated with library search, direct database search and de novo sequencing. PEAKS 13 supports data-dependent and data-independent acquisition analyses (DDA and DIA respectively) and ion mobility mass spectrometry (IMS-MS) with the IMS add-on module. As a vendor-neutral computing platform, PEAKS is capable of directly loading raw mass spectrometry data and standard data formats. Deploy the PEAKS workflows to identify the presence of peptides and proteins in your project for 1) DDA data analysis including de novo sequencing, PEAKS DB (database search) identification, PEAKS PTM (post translational modification) analysis, SPIDER homology search and PEAKS DeepNovo Peptidome (specialised workflow for peptidomics data) and 2) DIA data analysis including PEAKS DIA Workflow (spectral library search, direct database searching and de novo sequencing),and DeepNovo-DIA Peptidome.Quantification analysis by labelling and label-free quantification (LFQ) can also be performed using the PEAKS Q add-on module. Intuitive result visualisation tools are provided at every stage of analysis and results can be exported. Targeted data analysis includes PEAKS PRM Quantification and Hybrid-PRM/DIA.Newly Redesigned and Streamlined DDA and DIA Proteome and Peptidome Workflows
DDA
DIAWorkflows with common steps are now consolidated into the same workflow. Users can choose which point to finish the analysis and can easily add additional steps later.
Deeper Discovery with Sequence Variantsuence Variants
PEAKS 13 DIA can accurately identify sequence variants and novel peptides from a human dataset via a simulation test where an incorrect mouse database was used to search the human dataset. PEAKS could identify the correct human peptides through sequence variants compared to the mouse database and through the identification of novel peptides [1].
Furthermore, in our latest study [2] we demonstrate the accuracy of our new DIA solution for increased depth through cross-species validation test, addressing critical gaps in existing analytical frameworks:
Enhanced FDR control and result filteringSelecting report filters at both project and sample levels ensures a confident result.
使用 Top3 或 MaxLFQ 进行蛋白质定量
用户现在可以根据自己的研究需求选择 PEAKS DIA LFQ 中使用的定量算法。
具有序列变体的 PEAKS DIA 肽组DIA Peptidome 结合了强大的基于深度学习的 GraphNovo 进行肽段测序和序列变异分析，以提高和更可靠的鉴定结果[3]。LFQ 同时使用数据库找到的肽段和序列变体。
DDA Proteome now allows forlabelled and label free quantification for PEAKS PTM and SPIDER result. Intuitive results nodes combine the results from all steps of the search.
More flexible Targeted Proteomics workflowPEAKS targeted proteomics workflow is optimised for more flexibility and ready-to-use purpose. The workflow is separated into unlabelled and labelled workflow for different application scenarios. PRM PASEF (Bruker) is now supported in PEAKS 13.
通道列表生成器，用于轻松选择目标肽段新的 Transition List Generator 工具是作为发现蛋白质组学和靶向蛋白质组学之间的即用型干扰实现的。用户可以选择/可视化碎片离子和预定的通道。 
有兴趣联系
3766906032@qq.com
微博帐号登录